Tubastatin A

CAS No. 1252003-15-8

Tubastatin A ( —— )

Catalog No. M11010 CAS No. 1252003-15-8

Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in cell-free assays.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 30 In Stock
10MG 37 In Stock
50MG 65 In Stock
100MG 102 In Stock
200MG 155 In Stock
500MG 259 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Tubastatin A
  • Note
    Research use only, not for human use.
  • Brief Description
    Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in cell-free assays.
  • Description
    Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in cell-free assays; displays 57-fold selectivity over HDAC8 and >1,000-fold selective against other HDAC isoforms; induces an increase in acetylated-α-tubulin levels and the restoration of primary cilia expression in the cholangiocarcinoma cell lines at 10 uM, shows significant inhibition of TNF-α and IL-6 in LPS stimulated human THP-1 macrophages with IC50 of 272 nM and 712 nM; reduces the growth of cholangiocarcinoma in vivo.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC6
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1252003-15-8
  • Formula Weight
    335.40
  • Molecular Formula
    C20H21N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 45 mg/mL
  • SMILES
    CN1CCC2=C(C1)C1=CC=CC=C1N2CC1=CC=C(C=C1)C(=O)NO
  • Chemical Name
    Benzamide, N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Butler KV, et al. J Am Chem Soc. 2010 Aug 11;132(31):10842-6.
2. de Zoeten EF, et al. Mol Cell Biol. 2011 May;31(10):2066-78.
3. Gradilone SA, et al. Cancer Res. 2013 Apr 1;73(7):2259-70.
4. Vishwakarma S, et al. Int Immunopharmacol. 2013 May;16(1):72-8.
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