Tubastatin A
CAS No. 1252003-15-8
Tubastatin A ( —— )
Catalog No. M11010 CAS No. 1252003-15-8
Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in cell-free assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 30 | In Stock |
|
10MG | 37 | In Stock |
|
50MG | 65 | In Stock |
|
100MG | 102 | In Stock |
|
200MG | 155 | In Stock |
|
500MG | 259 | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameTubastatin A
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NoteResearch use only, not for human use.
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Brief DescriptionTubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in cell-free assays.
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DescriptionTubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in cell-free assays; displays 57-fold selectivity over HDAC8 and >1,000-fold selective against other HDAC isoforms; induces an increase in acetylated-α-tubulin levels and the restoration of primary cilia expression in the cholangiocarcinoma cell lines at 10 uM, shows significant inhibition of TNF-α and IL-6 in LPS stimulated human THP-1 macrophages with IC50 of 272 nM and 712 nM; reduces the growth of cholangiocarcinoma in vivo.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC6
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1252003-15-8
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Formula Weight335.40
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Molecular FormulaC20H21N3O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 45 mg/mL
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SMILESCN1CCC2=C(C1)C1=CC=CC=C1N2CC1=CC=C(C=C1)C(=O)NO
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Chemical NameBenzamide, N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Butler KV, et al. J Am Chem Soc. 2010 Aug 11;132(31):10842-6.
2. de Zoeten EF, et al. Mol Cell Biol. 2011 May;31(10):2066-78.
3. Gradilone SA, et al. Cancer Res. 2013 Apr 1;73(7):2259-70.
4. Vishwakarma S, et al. Int Immunopharmacol. 2013 May;16(1):72-8.
2. de Zoeten EF, et al. Mol Cell Biol. 2011 May;31(10):2066-78.
3. Gradilone SA, et al. Cancer Res. 2013 Apr 1;73(7):2259-70.
4. Vishwakarma S, et al. Int Immunopharmacol. 2013 May;16(1):72-8.
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