Tubastatin A

CAS No. 1252003-15-8

Tubastatin A ( —— )

Catalog No. M11010 CAS No. 1252003-15-8

Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in cell-free assays.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 30 In Stock
10MG 37 In Stock
50MG 65 In Stock
100MG 102 In Stock
200MG 155 In Stock
500MG 259 In Stock
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Biological Information

  • Product Name
    Tubastatin A
  • Note
    Research use only, not for human use.
  • Brief Description
    Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in cell-free assays.
  • Description
    Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in cell-free assays; displays 57-fold selectivity over HDAC8 and >1,000-fold selective against other HDAC isoforms; induces an increase in acetylated-α-tubulin levels and the restoration of primary cilia expression in the cholangiocarcinoma cell lines at 10 uM, shows significant inhibition of TNF-α and IL-6 in LPS stimulated human THP-1 macrophages with IC50 of 272 nM and 712 nM; reduces the growth of cholangiocarcinoma in vivo.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC6
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1252003-15-8
  • Formula Weight
    335.40
  • Molecular Formula
    C20H21N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 45 mg/mL
  • SMILES
    CN1CCC2=C(C1)C1=CC=CC=C1N2CC1=CC=C(C=C1)C(=O)NO
  • Chemical Name
    Benzamide, N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Butler KV, et al. J Am Chem Soc. 2010 Aug 11;132(31):10842-6.
2. de Zoeten EF, et al. Mol Cell Biol. 2011 May;31(10):2066-78.
3. Gradilone SA, et al. Cancer Res. 2013 Apr 1;73(7):2259-70.
4. Vishwakarma S, et al. Int Immunopharmacol. 2013 May;16(1):72-8.
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